Interaction of anthelmintic drug (thiabendazole) with DNA: Spectroscopic and molecular modeling studies
The interaction between thiabendazole (TBZ) and calf-thymus DNA (ct-DNA) was studied by experimental and molecular modeling methods.The intrinsic fluorescence of TBZ was quenched in the presence of ct-DNA.In competition experiments, TBZ could displace Hoechst 33258 (a minor groove binder to DNA), whereas it was unable to replace ethidium bromide (a